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There has been a global tightening of safety standards in response to rising concerns about counterfeit medications and unsafe drugs entering the market. National and international bodies, such as the World Health Organization (WHO) and the Ethiopian Food and Drug Authority (EFDA), have imposed more stringent regulations on pharmaceutical manufacturers and importers. Companies must now ensure that products undergo rigorous testing for quality and safety before they are approved for distribution. This includes adopting advanced traceability systems, ensuring cold chain compliance for temperature-sensitive products, and adhering to updated packaging and labeling requirements.